廣瀬さんたちの、転写ノイズQTL論文をbioRxivで公開しました。

Genome-wide identification and characterization of QTLs for transcriptional noise in human midbrain cells

Naoki HIROSE, Shota MIZUNO, Yuki NIWA, Tomonori HARA, Hirona YAMAMOTO, Emiko KOYAMA, Junko UEDA, Takashi TSUBOI, Atsushi TAKATA
https://www.biorxiv.org/content/10.1101/2025.02.01.635574v1
https://cbs.riken.jp/en/preprints/

Not only the abundance of gene expression but also its cell-to-cell variation, referred to as “transcriptional noise”, is known to have certain biological significance. However, the mechanistic basis of transcriptional noise, particularly how it is regulated by genetic variants, remains elusive. In this study, we analyzed single-cell RNA sequencing (scRNA-seq) data of human induced pluripotent stem cell (iPSC)-derived midbrain cells (795,661 cells in 17 conditions) from 155 individuals with their genotypes to perform genome wide mapping of quantitative trait loci for transcriptional noise (tnQTLs).